Three Divergent Subpopulations of the Malaria ParasitePlasmodium knowlesi

• DOI: 10.3201/eid2304.161738
• Publication Date: 2017-03-01T13:22:26Z
• Authors: Paul C.S. Divis; Lee C. Lin; Jeffrine J. Rovie...; Khamisah A. Kadir; Fread Anderios; Shamilah Hisam; Reuben S.K. Sharma; Balbir Singh; David J. Conway
• Keywords: Plasmodium knowlesi; Plasmodium (life cycle)

Abstract Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data have particularly deep between parasites from mainland Southeast Asia Borneo. To resolve overall population structure, multilocus conducted new sample 182 P. infections (obtained 134 48 wild macaques) diverse areas Malaysia, first analyzed separately then combination previous data. All analyses confirmed clusters human cases Malaysian long-tailed macaques pig-tailed macaques, third cluster most peninsular Malaysia. High levels pairwise these sympatric allopatric implications for epidemiology control this zoonotic