Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin1

• DOI: 10.3201/eid2306.161825
• Publication Date: 2017-04-20T13:56:45Z
• Authors: Iryna Bukreyeva; Adela Angoulvant; Inès Bendib; Jean-Charles Gagnard; Jean-Henri Bourhis; Sylvie Dargère; Julie Bonhomme; Marc Thellier; Bertrand Gachot; Benjamin Wyplosz
• Keywords: Enterocytozoon bieneusi; Fumagillin; Immunosuppression

Enterocytozoon bieneusi microsporidiosis is an emerging disease in immunocompromised patients. We report 2 cases of this allogeneic hematopoietic stem cell transplant patients successfully treated with fumagillin. Thrombocytopenia occurred but without major adverse events. Modifications immunosuppression could be avoided when E. rapidly identified and fumagillin therapy started promptly.