Enterovirus A71 Phenotypes Causing Hand, Foot and Mouth Disease, Vietnam

• DOI: 10.3201/eid2504.181367
• Publication Date: 2019-03-04T16:02:59Z
• Authors: Hoang Minh Tu Van; Nguyen To Anh; Nguyen Thi Thu Hong; Le Nguyen Truc Nhu; Lam Anh Nguyet; Tran Tan Thanh; Nguyen Thi Han Ny; Vu Thi Ty Hang; Truong Huu Khanh; Ho Lu Viet; Do Chau Viet; Ha Manh Tuan; Nguyen Thanh Hung; Du Tuan Quy; Do Quang Ha; Phan Tu Qui; Le Nguyen Thanh Nhan; Guy Thwaites; Nguyen Van Vinh Chau; Louise Thwaites; H. Rogier van Doorn; Le Van Tan
• Keywords: Hand-foot-and-mouth disease; Enterovirus 71

We investigated enterovirus A71-associated hand, foot and mouth disease in Vietnam found that, after replacing subgenogroup C4 2013, B5 remained the leading cause of this disease. In contrast with previous observations, switch did not result an explosive outbreak, evolution was driven by negative selection.