Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe

• DOI: 10.3201/eid2706.203096
• Publication Date: 2021-05-19T13:02:44Z
• Authors: Kimberley S.M. Be...; Eeva K. Broberg; Emma Hodcroft; Dennis Schmitz; Jan Albert; Anda Baicus; Jean-Luc Bailly; Gudrun Baldvinsdo...; Natasa Berginc; Soile Blomqvist; Sindy Böttcher; Mia Brytting; Erika Bujaki; Maria Cabrerizo; Cristina Celma; Ondrej Cinek; Eric C.J. Claas; Jeroen Cremer; Jonathan Dean; Jennifer L. Dembi...; Iryna Demchyshyna; Sabine Diedrich; Susanne Dudman; Jake Dunning; Robert Dyrdak; Mary Emmanouil; Agnes Farkas; Cillian De Gascun; Guillaume Fournier; Irina Georgieva; Ruben Gonzalez-Sanz; Jolanda van Hooyd...; Anne J. Jääskeläinen; Ruta Jancauskaite; Kathrin Keeren; Thea K. Fischer; Sidsel Krokstad; Lubomira Nikolaev...; Ludmila Novakova; Sofie E. Midgley; Audrey Mirand; Richard Molenkamp; Ursula Morley; Joël Mossong; Svajune Muralyte; Jean-Luc Murk; Trung Nguyen; Svein A. Nordbø; Riikka Österback; Suzan Pas; Laura Pellegrinelli; Vassiliki Pogka; Birgit Prochazka; Petra Rainetova; Marc Van Ranst; Lieuwe Roorda; Isabelle Schuffen...; Rob Schuurman; Asya Stoyanova; Kate Templeton; Jaco J. Verweij; Androniki Voulgar...; Tytti Vuorinen; Elke Wollants; Katja C. Wolthers; Katherina Zakikhany; Richard Neher; Heli Harvala; Peter Simmonds
• Keywords: Echovirus; Molecular Epidemiology

In 2018, an upsurge in echovirus 30 (E30) infections was reported Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected 22 countries Europe during 2016-2018. Most cases affected persons 0-4 years age (29%) 25-34 (27%). Sequences were divided into 6 genetic clades (G1-G6). (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 displayed >2 forms. Rapid turnover new forms occurred over time. Clades dominated suggesting the caused emergence 2 distinct circulating Investigation mechanisms behind rapid is crucial for clarifying epidemiology evolution these enterovirus infections.