Direct and Indirect Effectiveness of mRNA Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 in Long-Term Care Facilities, Spain

• DOI: 10.3201/eid2710.211184
• Publication Date: 2021-09-21T16:01:11Z
• Authors: Susana Monge; Carmen Olmedo; Belén Alejos; María Fé Lapeña; María José Sierra; Aurora Limia
• Keywords: COVID-19 Vaccines; SARS-CoV-2; Research; Vaccination; R; COVID-19; Infectious and parasitic diseases; RC109-216; Long-Term Care; 3. Good health; Cohort Studies; respiratory infections; 03 medical and health sciences; 0302 clinical medicine; coronavirus disease; Spain; Medicine; Humans; viruses; RNA, Messenger; BNT162 Vaccine; severe acute respiratory syndrome coronavirus 2

We conducted a registries-based cohort study of long-term care facility residents >65 years age offered vaccination against severe acute respiratory syndrome coronavirus 2 before March 10, 2021, in Spain. Risk for infection vaccinated and nonvaccinated persons was compared with risk the same period campaign, adjusted by daily-varying incidence reproduction number. selected 299,209 persons; 99.0% had >1 dose, 92.6% doses, 99.8% vaccines were Pfizer/BioNTech (BNT162b2). For no previous infection, vaccine effectiveness 81.8% (95% CI 81.0%-82.7%), 11.6 11.3-11.9) cases prevented per 10,000 vaccinated/day. In those 56.8% 47.1%-67.7%). decreased up to 81.4% 73.3%-90.3%). Our results confirm this population suggest indirect protection persons.