Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis1

• DOI: 10.3201/eid2711.211174
• Publication Date: 2021-10-20T03:31:58Z
• Authors: Nico A.F. Janssen; Rémy Nyga; Lore Vanderbeke; Cato Jacobs; Mehmet Ergün; Jochem B. Buil; Karin van Dijk; Josje Altenburg; Catherine S.C. Bo...; Hans I. van der S...; Bart J.A. Rijnders; Albert Dunbar; Jeroen A. Schouten; Katrien Lagrou; Marc Bourgeois; Marijke Reynders; Niels van Regenmo...; Lynn Rutsaert; Piet Lormans; Simon Feys; Yves Debavaye; Fabienne Tamion; Damien Costa; Julien Maizel; Hervé Dupont; Taieb Chouaki; Saad Nseir; Boualem Sendid; Roger J.M. Brügge...; Frank L. van de V...; Joost Wauters; Paul E. Verweij
• Keywords: Diagnosis and Management of Fungal Infections; 0301 basic medicine; 570; Epidemiology; Virulence Factors; [SDV]Life Sciences [q-bio]; Radboud University Medical Center; Infectious disease (medical specialty); FOS: Health sciences; Epidemiology and Management of Fungal Infections; Cohort Studies; Betacoronavirus; 03 medical and health sciences; SDG 3 - Good Health and Well-being; Observational study; Virology; 616; Health Sciences; Humans; Intensive care medicine; Disease; Internal medicine; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences; Invasive Pulmonary Aspergillosis; 0303 health sciences; SARS-CoV-2; Epidemiology and Pathogenesis of Pneumocystis Pneumonia; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Cohort; COVID-19; Outbreak; 3. Good health; [SDV] Life Sciences [q-bio]; Coronavirus disease 2019 (COVID-19); Infectious Diseases; Medicine; Pulmonary Aspergillosis; Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences; Cohort study; 2019-20 coronavirus outbreak

Realizamos un estudio observacional para investigar la incidencia en la unidad de cuidados intensivos, los factores de riesgo y los resultados de la aspergilosis pulmonar asociada a la enfermedad por coronavirus (capa). Encontramos una incidencia de capa del 10%-15% entre 823 pacientes en 2 cohortes. Varios factores se asociaron independientemente con capa en 1 cohorte y las tasas de mortalidad fueron del 43%-52%.<br/>أجرينا دراسة رصدية للتحقيق في حدوث وحدة العناية المركزة وعوامل الخطر ونتائج داء الرشاشيات الرئوي المرتبط بفيروس كورونا (CAPA). وجدنا 10 ٪-15 ٪ من حالات CAPA بين 823 مريضًا في مجموعتين. ارتبطت عدة عوامل بشكل مستقل مع CAPA في مجموعة واحدة وكانت معدلات الوفيات 43 ٪-52 ٪.<br/>Nous avons réalisé une étude observationnelle pour étudier l'incidence, les facteurs de risque et les résultats de l'aspergillose pulmonaire associée à la maladie à coronavirus (CAPA) dans les unités de soins intensifs. Nous avons trouvé une incidence de 10 % à 15 % de CAPA chez 823 patients dans 2 cohortes. Plusieurs facteurs ont été indépendamment associés à la CAPA dans 1 cohorte et les taux de mortalité étaient de 43 % à 52 %.<br/>We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%-52%.<br/>