Natural History of and Dynamic Changes in Clinical Manifestation, Serology, and Treatment of Brucellosis, China

• DOI: 10.3201/eid2807.211766
• Publication Date: 2022-06-21T12:37:11Z
• Authors: Hongyu Wang; Hongyan Liu; Qiran Zhang; Xiaobo Lu; Dan Li; Haocheng Zhang; Yan A. Wang; Rongjiong Zheng; Yi Zhang; Zhangfan Fu; Ke Lin; Chao Qiu; Yan O. Wang; Ye Gu; Jingwen Ai; Wenhong Zhang
• Keywords: 0301 basic medicine; China; 0303 health sciences; Hematologic Tests; R; Dispatch; dynamic surveillance; Infectious and parasitic diseases; RC109-216; Antibodies, Bacterial; Brucella; Brucellosis; zoonoses; 3. Good health; 03 medical and health sciences; Agglutination Tests; Medicine; Humans; bacteria

Serum agglutination test plus exposure history were used to diagnose most cases of human brucellosis in 2 China provinces. After appropriate treatment, 13.3% of acute brucellosis cases progressed to chronic disease; arthritis was an early predictor. Seropositivity can persist after symptoms disappear, which might cause physicians to subjectively extend therapeutic regimens.