Risk for Severe Illness and Death among Pediatric Patients with Down Syndrome Hospitalized for COVID-19, Brazil

• DOI: 10.3201/eid2901.220530
• Publication Date: 2023-01-03T16:51:08Z
• Authors: Char Leung; Li Su; Ana Cristina Simõ...; Luisamanda Selle ...; Karina Mary de Paiva; Patricia Haas
• Keywords: 2019-20 coronavirus outbreak; Betacoronavirus; Pandemic

Abstract Down syndrome is the most common human chromosomal disorder. Whether a risk factor for severe COVID-19 outcomes in pediatric patients remains unclear, especially low-to-middle income countries. We gathered data on <18 years of age with SARS-CoV-2 infection from national registry Brazil to assess among syndrome. included 14,684 hospitalized patients, 261 whom had After adjustments sociodemographic and medical factors, 1.8 times higher odds dying (odds ratio 1.82, 95% CI 1.22–2.68) 27% longer recovery (hazard 0.73, 0.61–0.86) than without found was associated increased illness death patients. Guidelines managing could improve this population.