Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China

• DOI: 10.3201/eid3006.230530
• Publication Date: 2024-05-21T14:59:25Z
• Authors: Yang Liu; Yuhua Chen; Zhiyi Yang; Yaozhong Lin; Siyuan Fu; Junhong Chen; Lingyu Xu; Tengfei Liu; Beibei Niu; Qiuhong Huang; Haixia Liu; Chaofeng Zheng; Ming Liao; Weixin Jia
• Keywords: 0301 basic medicine; China; Hemagglutinin Glycoproteins, Influenza Virus; Infectious and parasitic diseases; RC109-216; Influenza A Virus, H7N9 Subtype; H7N9; Evolution, Molecular; Birds; 03 medical and health sciences; evolution; Influenza, Human; Animals; Humans; Antigens, Viral; Phylogeny; antigenic drift; R; Dispatch; Antigenic Variation; zoonoses; Influenza in Birds; Viruses; Medicine; avian influenza

We characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease prevention and control.