Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction

• DOI: 10.3233/978-1-61499-564-7-946
• Publication Date: 2025-02-21T16:48:36Z
• Authors: Caraballo Pedro J.; Parkulo Mark; Blair David; Elliott Michelle; Schultz Cloann; Sutton Joseph; Rao Padma; Bruflat Jamie; Bleimeyer Robert; Crooks John; Gabrielson Donald; Nicholson Wayne; Rohrer Vitek Car...; Wix Kelly; Bielinski Suzett...; Pathak Jyotishman; Kullo Iftikhar
• Keywords: Pharmacogenomics; Health records; Concomitant

The level of CYP2D6 metabolic activity can be predicted by pharmacogenomic testing, and concomitant use clinical decision support has the potential to prevent adverse effects from those drugs metabolized this enzyme. Our initial findings after implementation alerts integrated in electronic health records suggest high feasibility, but also identify important challenges.