Molecular prevalence of human papillomavirus infection among Iranian women with breast cancer

• DOI: 10.3233/bd-180333
• Publication Date: 2018-08-14T19:52:38Z
• Authors: Hadi Ghaffari; Nahid Nafissi; Mohammad Hashemi-...; Mahmoud Reza Aleb...; Ahmad Tavakoli; Davod Javanmard; Farah Bokharaei-S...; Helya Sadat Morta...; Seyed Hamidreza M...
• Keywords: Adult; Paraffin Embedding; Genotype; Papillomavirus Infections; Breast Neoplasms; Iran; Middle Aged; Polymerase Chain Reaction; 3. Good health; 03 medical and health sciences; Cell Transformation, Neoplastic; 0302 clinical medicine; DNA, Viral; Prevalence; Humans; Female; Papillomaviridae

The etiology and molecular mechanisms involved in the development of breast cancer still remain poorly understood. Some epidemiological studies have shown an association between human papillomavirus (HPV) cancer. However, findings are controversial.Our study was aimed to investigate presence HPV DNA carcinomas Iranian women.In total, 72 samples formalin-fixed paraffin-embedded (FFPE) tissues collected December 2014 April 2016 were examined. detection performed by nested-PCR assay. Next, positive subjected genotyping CLART HPV2 microarray system. All statistical analysis carried out using SPSS v.18.0.HPV detected 4/72 (5.55%) samples. Clinical factors not statistically associated with presence. assay failed determine genotype any samples.The low frequency our does support carcinoma infection. it is possible that may be responsible for carcinogenesis only small percentage all