High serum TIMP-1 correlates with poor prognosis in breast carcinoma – A validation study

• DOI: 10.3233/cbm-2007-3603
• Publication Date: 2017-01-31T16:42:28Z
• Authors: P. Kuvaja; S.Ø. Würtz; A. Talvensaari-Ma...; N. Brünner; P. Pääkkö; T. Turpeenniemi-H...
• Keywords: Breast carcinoma; Breast tumor

A number of studies have demonstrated that high tumor tissue levels inhibitor metalloproteinases-1 (TIMP-1) are associated with a poor prognosis in breast cancer, suggesting TIMP-1 could be valid prognostic marker this disease. Recently, our laboratories presented results showing also carries information when measured serum. This is an important finding, since serum much more preferable material compared extracts. The aim the present study was to validate previous concerning value obtained preoperatively from 68 patients primary cancer. done by measuring same samples as but different laboratory using ELISA assay. We confirmed highest (> 197.7 ng/ml) had significantly shorter disease-specific survival low levels. In group node-negative patients, 53% survived after 10 years follow-up 92% thus confirms reproducibility across investigated whether measurements specific fraction uncomplexed improved serum, has been shown case for However, including level did not seem provide additional already provided total TIMP-1.