A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer

• DOI: 10.3233/cbm-230190
• Publication Date: 2023-12-06T12:10:36Z
• Authors: Yang Liu; Yan-Song Han; Jin-Feng Wang; Zhong-Qi Pang; Jian-She Wang; Lu Zhang; Jia-Xin He; Lin-Kun Shen; Bo Ji; Bei-Chen Ding; Ming-Hua Ren

The biological roles of immune-related genes (IRGs) in bladder cancer (BC) need to be further elucidated.To elucidate the predictive value IRGs for prognosis and immune escape BC.We comprehensively analyzed transcriptomic clinical information 430 cases, including 19 normal 411 BC patients from TCGA database, verified 165 cases GSE13507 dataset. risk model was constructed based on by applying LASSO Cox regression exploring relationship between score prognosis, gene mutations, patients.We identified 4 survival-related (PSMC1, RAC3, ROBO2 ITGB3) among 6,196 both GES13507 datasets,, which were used establish a regression. results showed that high-risk (HR) group closely associated with poor survival or advanced pathological stage BC. Furthermore, found an independent factor patients. In addition, individuals greater prevalence TP53 mutations lower CD8+ T-cell NK cell infiltration, higher Treg expression PD-L1, exclusion scores than those low-risk (LR) group. Finally, experimental verification shows construction gene, especially PMSC1, plays important role growth metastasis cancer.These evidences revealed vital predicting mutation