Associations between Neuropsychiatric Symptoms and Cerebral Amyloid Deposition in Cognitively Impaired Elderly People

• DOI: 10.3233/jad-150181
• Publication Date: 2015-11-27T13:35:17Z
• Authors: David Bensamoun; ; Renaud Guignard; Ansgar J. Furst; Alexandre Derreumaux; Valeria Manera; Jacques Darcourt; Michel Benoit; Philippe H. Robert; Renaud David
• Keywords: Irritability; Clinical Dementia Rating; Mini–Mental State Examination; Posterior cingulate

Background: Neuropsychiatric symptoms, also known as behavioral and psychological symptoms of dementia (BPSD), affect the majority patients with dementia, result in a greater cognitive functional impairment. Objective: To investigate associations between BPSD amyloid cerebral deposition measured by 18F-Florbetapir-PET quantitative uptake elderly subjects without Methods: Participants impairment [mild (MCI) or Alzheimer’s disease (AD)] healthy controls (HC) from ADNI cohort (Alzheimer Disease Neuroimaging Initiative) who underwent an 18F-florbetapir PET scan May 2010 March 2014 were included. Clinical assessments included Dementia Rating, Mini-Mental State Examination (MMSE), Inventory. Freesurfer software was used to extract counts based on T1-based structural ROI (frontal, cingulate, parietal, temporal). Spearman’s partial correlation scores severity regional calculated. Results: Data for 657 participants [age = 72.6 (7.19); MMSE 27.4 (2.67)] analyzed, including 230 HC 73.1 (6.02); 29 (1.21)], 308 MCI 71.5 (7.44); 28.0 (1.75)], 119 AD 74.7 (8.05); 23.1 (2.08)]. Considering all diagnostic groups together, positive significant correlations found anxiety frontal (r 0.102; p 0.009), cingulate 0.083; 0.034), global 0.099; 0.011); irritability 0.089; 0.023), 0.085; 0.030), parietal 0.087; 0.025), 0.093; 0.017); subgroup, 0.126; 0.03) 0.14; 0.013); 0.201; 0.03). Conclusion: Anxiety are associated neurodegenerative process leading AD.