Multimodal Imaging Evidence for Axonal and Myelin Deterioration in Amnestic Mild Cognitive Impairment

• DOI: 10.3233/jad-2012-112165
• Publication Date: 2018-05-16T08:52:54Z
• Authors: Brian T. Gold; Yang Jiang; David K. Powell; Charles D. Smith
• Keywords: Male; Brain; Neuropsychological Tests; Hippocampus; Magnetic Resonance Imaging; Axons; 03 medical and health sciences; Diffusion Tensor Imaging; 0302 clinical medicine; ROC Curve; Image Processing, Computer-Assisted; Anisotropy; Humans; Cognitive Dysfunction; Female; Amnesia; Atrophy; Myelin Sheath; Aged; Demography

White matter (WM) microstructural declines have been demonstrated in Alzheimer's disease and amnestic mild cognitive impairment (aMCI). However, the pattern of WM changes aMCI after controlling for atrophy is unknown. Here, we a