The Efficacy of Desmopressin and Imipramine in Retaining the Instilled Suspension in the Bladder

• DOI: 10.32388/r13bbi
• Publication Date: 2024-09-06T14:48:41Z
• Authors: Masoud Bitaraf; Saman Behboodi Ta...; Erfan Amini; Ashkan Azimzadeh; Samad Muhammadnejad; Sara Mohammdi; Masoumeh Majidi Z...; Abdol-Mohammad Ka...
• Keywords: Desmopressin; Suspension

OBJECTIVE: To assess the efficacy of desmopressin and imipramine in reducing urination frequency, retaining instilled suspension bladder without maintaining mouse under anesthesia. METHOD: Twenty-four mice were divided into four groups: (1) control, (2) four-hour water deprivation, (3) two µg/kg intraperitoneal desmopressin, (4) plus 30 mg/kg gavage. Micturition frequency was recorded using voiding spot assay. Animals catheterized 50 µl methylene blue bladder. The then placed on a white paper to recover. Blue documented. RESULTS: Urination significantly lower group. water-deprived desmopressin/imipramine-combination groups did not differ compared control All animals voided upon recovery. CONCLUSION: Desmopressin notably reduced frequency. In contrast, deprivation do so. failed cause retention awake mice.