Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway

• DOI: 10.32604/or.2023.029549
• Publication Date: 2023-07-26T13:46:46Z
• Authors: TIANYING CAI; JUNJIE BAI; PENG TAN; ZHIWEI HUANG; CHEN LIU; ZIMING WU; YONGLANG CHENG; TONGXI LI; YIFAN CHEN; JIAN RUAN; LIN GAO; YICHAO DU; WENGUANG FU
• Keywords: Carcinoma, Hepatocellular; Cell Movement; Cell Line, Tumor; TOR Serine-Threonine Kinases; Liver Neoplasms; Humans; Proto-Oncogene Proteins c-akt; Article; Zyxin; 3. Good health; Cell Proliferation; Signal Transduction

Hepatocellular carcinoma (HCC) is a common malignancy that driven by multiple genes and pathways. The aim of this study was to investigate the role specific mechanism actin-interacting protein zyxin (ZYX) in HCC. We found expression ZYX significantly higher HCC tissues compared normal liver tissues. In addition, overexpression hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration invasion, whereas knockdown had opposite effects (SK HEP-1, Huh-7). Furthermore, change levels also altered proteins related cycle, invasion. Similar results were obtained with xenograft models. AKT/mTOR signaling pathway one key mediators cancer development. While upregulated phosphorylated proteins, its effect. AKT inhibitor MK2206 neutralized pro-oncogenic on cells, activator SC79 restored invasion cells knockdown. Taken together, promotes malignant progression activating pathway, potential therapeutic target