Effects of topical hyaluronic acid on nasal mucosa wound healing

• DOI: 10.32637/orli.v54i2.544
• Publication Date: 2025-02-03T15:53:50Z
• Authors: Lidya Sabig; Anna Mailasari Ku...; Riece Hariyati; Vega Karlowee; Faiza Rizky Aryan...

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal and paranasal sinuses mucosa that takes place for more than 3 months. The treatment paradigm nowadays depends on Functional Endoscopic Sinus Surgery (FESS) in hope to repair damaged mucosa, restoring it its physiological condition. Hyaluronic Acid (HA) could restore natural barrier stop cascade. Purpose: To understand difference number cells post-FESS CRS patients had been treated with HA. Method: This was pre post-test, double-blinded, randomized control group study design 22 (range 18 55 years) Dr. Kariadi General Hospital, Semarang from May August 2019. All subjects undergone biopsies inferior turbinate at time surgery 4 weeks after surgery. post-test neutrophil, eosinophil lymphocyte counts were compared between groups. neutrophil-to-lymphocyte ratio (NLR) eosinophil-to- (ELR) levels also two Data analysis done using Wilcoxon test. Result: When compared, no statistically significant found groups except ELR (p=0.028). Conclusion: decreased significantly group. NLR level but not significant. shown topical HA positively modulate response. Keywords: rhinosinusitis, FESS, histopathology, eosinophil, ABSTRAK Latar belakang: Rinosinusitis kronis (RSK) merupakan penyakit inflamasi kronik pada mukosa hidung dan sinus yang berlangsung lebih dari 12 minggu. Bedah Endoskopi Fungsional (BSEF) RSK bertujuan untuk memperbaiki rusak mengembalikannya ke kondisi fisiologis. Asam hyaluronat (AH) dapat mengembalikan penghalang alami menghentikan proses inflamasi. Tujuan: Untuk mengetahui perbedaan jumlah sel pasca BSEF pasien diberikan terapi tambahan AH. Metode: Penelitian ini penelitian tersamar ganda, desain kelompok kontrol acak terhadap (berusia hingga tahun) di RS Kariadi, bulan Mei Agustus Semua subjek dilakukan biopsi konka saat operasi minggu setelah operasi. Jumlah neutrofil, eosinofil, limfosit sebelum sesudah dibandingkan antara perlakuan. Rasio neutrofil rasio eosinofil juga kedua kelompok. Analisis data dengan menggunakan uji Wilcoxon. Hasil: Hasil perbandingan perlakuan terapi, menunjukkan tidak ada signifikan secara statistik kecuali (p=0,028). Kesimpulan: menurun Tingkat tetapi signifikan. bahwa AH topikal positif memodulasi respon Kata kunci: rinosinusitis kronis, BSEF, histopatologi,