Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis

• DOI: 10.32867/inakidney.v1i2.134
• Publication Date: 2024-08-26T01:21:49Z
• Authors: Lusito Lusito; Lestariningsih Le...; Dwi Lestari Parti...; Shofa Chasani; Arwedi Arwanto; Ayudyah Nurani; Fadhli Rizal Makarim
• Keywords: Single Center; Chronic renal insufficiency

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability convert vitamin into the active form of calcitriol, which crucial for controlling cell inflammation. Low levels are associated increased inflammation and higher biomarkers such as c-reactive protein asymmetric dimethylarginine an endogenous inhibitor nitric oxide synthase. Those two combined become specific marker cardiovascular diseases, one causes CKD mortality. Objective: This study examines correlation between insufficiency, elevated high-sensitivity protein, in receiving hemodialysis. Methods: used cross-sectional design hemodialysis Dr. Kariadi Central General Hospital, Semarang, Indonesia, November 2021. Thirty-six were randomly enrolled after meeting inclusion exclusion criteria. Primary outcomes D, hs-CRP, ADMA measured from patients’ blood A statistical analysis Pearson's was primary outcomes. Results: No significant difference found patient's baseline characteristics. has been found; however, no hs-CRP Conclusion: correlated ADMA, indicative endothelial dysfunction.