Los valores de corte de circunferencia de cintura para predecir el síndrome metabólico en adolescentes obesos

• DOI: 10.3305/nh.2015.31.4.8442
• Publication Date: 2015-01-01
• Authors: Landi Masquio, De...; Piano Ganen, Alin...; Campos, Raquel Mu...; Lima Sanches, Pri...; Campos Corgosinho...; Caranti, Danielle; Tock, Lian; Mello, Marco Túli...; Tufik, Sergio; Dâmaso, Ana R
• Keywords: Síndrome metabólico; Male; Metabolic Syndrome; La enfermedad de hígado graso no alcohólico y la inflamación; Adolescent; Cortaron punto; Metabolic syndrome; Non-alcoholic fatty liver disease and inflammation; Body Mass Index; Young Adult; Cross-Sectional Studies; Predictive Value of Tests; Reference Values; Body Composition; Waist circumference; Humans; Cut off point; Female; Circunferencia de la cintura; Obesity; Waist Circumference

Metabolic syndrome (MetS) is a constellation of metabolic alteration related to abdominal obesity, inflammation and insulin resistance, which increase cardiovascular disease and mortality. The aims of the present study were to identify the prevalence of comorbidities and altered parameters in obese adolescents with and without MetS, and determine cut-off points of waist circumference to predict MetS.195 obese adolescents were recruited and divided according to MetS diagnosis based on IDF criteria. Blood analyses of glucose, lipids, liver enzymes, adiponectin and leptin were measured. Insulin resistance was assessed by HOMA-IR, QUICKI and HOMA-AD. Visceral, subcutaneous and hepatic fat were ultrasonography obtained. Body composition was estimated by BOD POD system.We observed a prevalence of 25% of MetS (n=50). The MetS group presented significant higher body mass, BMI, body fat (kg), free-fat mass (kg), waist circumference, visceral fat, glucose, insulin, insulin resistance, total-cholesterol, LDL-c, VLDL-c, triglycerides, liver enzymes, non-alcoholic fatty liver disease (NAFLD) and blood pressure. Significant lower QUICKI and adiponectin in MetS group were noted. MetS girls presented significant higher leptin/adiponectin ratio compared to Non-MetS girls. Cut-off points of 111.5 cm for boys and 104.6 cm for girls of waist circumference were suggested to predict metabolic syndrome. Moreover, waist circumference was positive correlated with visceral fat and the number of metabolic syndrome parameters.MetS group presented significant higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice.