Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK

• DOI: 10.3310/nihropenres.13669.1
• Publication Date: 2024-11-06T16:30:07Z
• Authors: Helen Crisp; Oliver Tavabie; Yvanne Enever; Richard Allen; Milton Silverman; Juan Acevedo; Abhishek Chauhan; Brian Hogan; Vishal Patel; Rajeshwar Mookerjee; Gavin Wright; Richard Aspinall; Stuart McPherson; Andrew Cook; Rajiv Jalan; Gautam Mehta
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 610

Liver disease is a major, and increasing, cause of death in the UK. The UK Chronic Failure network (UK-CLIF) was developed as multi-stakeholder with aim to advance cirrhosis research, emphasis on geographical areas high prevalence or limited research activity. process involved development through dissemination snowball sampling techniques, monitoring connections between participants, over two online meetings. Network membership included representatives from patients, carers, clinicians, researchers, R&D professionals, industry representatives, third sector. Subsequently, facilitated in-person workshops were conducted participants. World Café methodology participant dot voting used develop priority consensus in: (i) infrastructure for clinical trials, (ii) factors affecting delivery, (iii) priorities future trials. Thematic analysis demonstrated that need patient-centric trial materials, lack resource clinicians participate variability standard inpatient care cirrhosis, barriers Future activities UK-CLIF include participation quality setting coordination James Lind Alliance Priority Setting Partnership questions liver cirrhosis.