Portal vein thrombosis in patients with hepatocellular carcinoma and early cirrhosis – prevalence and risk factors

• DOI: 10.3332/ecancer.2023.1581
• Publication Date: 2023-07-26T13:00:35Z
• Authors: Muhammad Tayyab U...; Ghulam Fareed; Muhammad Rizwan Khan; Amna Riaz; Saeed Sadiq Hamid
• Keywords: Portal vein thrombosis; Liver function

Introduction: Hepatocellular carcinoma (HCC) is frequently associated with portal vein thrombosis (PVT) prevalence ranging from 25% to 50%.PVT poor prognosis, limiting the available therapeutic options for these patients.Our objective was determine and risk factors PVT in patients HCC.Method: A retrospective analysis performed on prospectively collected data January 2018 March 2020.All HCC discussed our weekly multidisciplinary liver clinic were reviewed.Multivariate done identify independent patients.A p-value of <0.05 considered significant.Result: Of 316 patients, 31% (n = 98).Larger tumour size (p < 0.001), raised Alpha Fetoprotein (AFP) level 0.036) higher Child-Pugh class 0.008) significantly PVT.In 216 preserved function (Child-Pugh A), seen 53 (24.5%) patients.Large 0.001) AFP levels 0.021) factors. Conclusion:Overall whereas 24.5% early cirrhosis A).We identified various local population, highlighting importance regular screening cirrhotic including A.