ESBL and carbapenemase-producing Enterobacteriaceae in infectious pleural effusions: current epidemiology at Hôpital du Mali

• DOI: 10.33393/dti.2023.2613
• Publication Date: 2023-08-29T09:45:29Z
• Authors: Aimé Césaire Kala...; Tchamou Malraux F...; Ibrehima Guindo; Ambara Kassogué; Boubacar Sidiki I...; Seydou Togo; Sadio Yena; Seydou Doumbia; Mahamadou Diakite
• Keywords: Carbapenem-resistant enterobacteriaceae

Antimicrobial resistance (AMR) is a global health concern, with extended-spectrum β-lactamases (ESBLs) and carbapenemases being major contributors. Pleural infection (PI) severe condition in West Africa, complicated by AMR. This study aimed to investigate the prevalence molecular characteristics of ESBL carbapenemase-producing enterobacteria pleural effusions Mali.Pleural fluid samples from 526 patients pleuritis were analyzed. Enterobacterial species isolated identified, genes (blaOXA-48, blaNDM-1, blaKPC, blaTEM, blaSHV) virulence factors was determined.Among patients, 110 diagnosed enterobacterial pleuritis. Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis main pathogens identified. Resistance β-lactams cephalosporins high, while carbapenems showed good activity. production detected 33.6% isolates, blaTEM most common gene. Carbapenemase gene (blaNDM-1) found three isolates.The highlights high multidrug-resistant bacteria need for appropriate antibiotic selection based on local patterns. Understanding crucial optimizing patient care developing effective therapeutic strategies. Further research needed monitor control AMR PIs Mali.