Role of IgG, IgA, and IgE Antibodies in Nasal Polyp Tissue: Their Relationships with Eosinophilic Infiltration and Degranulation

• DOI: 10.3346/jkms.2002.17.3.375
• Publication Date: 2014-09-19T06:52:00Z
• Authors: Kyung Sik Suh; Hae Sim Park; Dong Ho Nahm; Yoon Keun Kim; Young Mok Lee; Keehyun Park
• Keywords: Dermatophagoides pteronyssinus; Immunoglobulins; Blood Proteins; Eosinophil Granule Proteins; Immunoglobulin E; Cell Degranulation; Immunoglobulin A; 3. Good health; Eosinophils; 03 medical and health sciences; Nasal Polyps; Ribonucleases; 0302 clinical medicine; Immunoglobulin G; Humans

To confirm local production of IgE, and evaluate role immunoglobulins on eosinophil activation in nasal polyp (NP) tissue, we measured IgG, IgA, secretory IgA(sIgA), total (tIgE) specific IgE (sIgE) to Dermatophagoides pteronyssinus(DP) by ELISA NP tissue homogenates from 51 subjects. They were classified according skin reactivity DP: group I, 15 highly atopic subjects; II, 18 weakly III, non-atopic Eosinophil cationic protein (ECP) level was CAP system. Highest DP-sIgE noted followed II III (p<0.05). Nine (60%) I 4 (22%) subjects had detectable with no significant differences sIgA, IgG. All eosinophilic infiltration difference activated count or ECP among 3 groups. A correlation between EG2+ cell tIgE (r=0.55, p<0.05), (r=0.60, p<0.05). also IgG (r=0.51, p<0.05) (r=0.47, IgA sIgA. These results suggest that as well sIgE may have potential roles degranulation tissue.