X-chromosome Inactivation Patterns in Korean Women with Idiopathic Recurrent Spontaneous Abortion

• DOI: 10.3346/jkms.2004.19.2.258
• Publication Date: 2010-02-10T07:50:17Z
• Authors: Jin-Woo Kim; So-Yeon Park; Young-Mi Kim; Jin-Mee Kim; Jung-Yeol Han; Hyun-Mee Ryu
• Keywords: Heterozygote advantage; Skewed X-inactivation

Recurrent spontaneous abortion (RSA) defines as two or more consecutive losses at < = 20 weeks of gestation and affects an estimated 1 every 100 couples wishing to have children. However, it remains a poorly understood phenomenon. Recent reports observed significant association between highly skewed X chromosome RSA, supporting that inactivation might be important previously unknown cause RSA. X-inactivation pattern, using polymeric X-linked women with idiopathic RSA 80 control subjects single successful pregnancy no history abortion. The ratio heterozygotes was 68.2% (45/66) in 67.5% (54/80) group. Among 45 informative cases, only (2.2%) woman showed extreme (> 90%) 4 (8.9%) had mild 85%). In 54 heterozygous subjects, 5 (9.3%) 7 (13.0%) one. frequency patients group not significantly different (p>0.05). This finding suggests x associated unexplained patients.