Stereotactic Body Radiotherapy for Isolated Para-aortic Lymph Node Recurrence after Curative Resection in Gastric Cancer

• DOI: 10.3346/jkms.2009.24.3.488
• Publication Date: 2009-06-19T00:14:27Z
• Authors: Mi-Sook Kim; Sung Yul Yoo; Chul Koo Cho; Hyung Jun Yoo; Kwang Mo Yang; Jin Kyu Kang; Dong Han Lee; Jong Inn Lee; Ho Youn Bang; Min Suk Kim; Hae Jin Kang
• Keywords: Adult; Male; Radiotherapy Dosage; Middle Aged; Radiosurgery; Survival Analysis; Disease-Free Survival; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Recurrence; Stomach Neoplasms; Lymphatic Metastasis; Humans; Original Article; Female; Lymph Nodes; Neoplasm Recurrence, Local; Aged

The aim of this study was to investigate whether stereotactic body radiotherapy (SBRT) can salvage gastric cancer patients with para-aortic lymph node (PALN) recurrence. From January 2003 to December 2006, 7 patients were treated for isolated PALN recurrence from gastric cancer after curative resection. Follow up durations ranged from 19 to 33 months (median; 26 months), and SBRT doses from 45 Gy to 51 Gy (median 48 Gy) in 3 fractions. Disease progression-free and overall survivals and toxicities were recorded. Response to treatment was assessed by computed tomography. Final patient outcomes were as follows: 2 were alive without evidence of disease, 3 remained alive with disease, and 2 patients died of disease. Five of 7 patients showed complete response and 2 patients partial response between 3 and 11 months after SBRT. Three-year overall and disease progression-free survival rates post-SBRT were 43% and 29%, respectively. No severe complication was detected during follow-up. Selected patients with isolated PALN recurrence can be salvaged by SBRT without severe complications.