Comparison of the Child-Turcotte-Pugh Classification and the Model for End-stage Liver Disease Score as Predictors of the Severity of the Systemic Inflammatory Response in Patients Undergoing Living-donor Liver Transplantation

• DOI: 10.3346/jkms.2011.26.10.1333
• Publication Date: 2011-10-12T09:33:21Z
• Authors: Sang-Hyun Hong; Jeong-Eun Kim; Mi-La Cho; Yu-Jung Heo; Jong-Ho Choi; Jung-Hyun Choi; Jaemin Lee
• Keywords: Liver disease

The aim of this study was to evaluate and compare the Child-Turcotte-Pugh (CTP) classification system model for end-stage liver disease (MELD) score in predicting severity systemic inflammatory response living-donor transplantation patients.Recipients graft were allocated a recipient group (n = 39) healthy donors donor 42).The association between CTP classification, MELD scores perioperative cytokine concentrations evaluated.The pro-inflammatory cytokines measured included interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α; anti-inflammatory IL-10 IL-4.Cytokine quantified using sandwich enzyme-linked immunoassays.The TNF-α, significantly higher than those patients.All preoperative levels, except increased relation disease, as by classification.Additionally, all correlated preoperatively with scores.However, correlations diminished during intraoperative period.The are equally reliable response, but only period.