Waldenstrom Macroglobulinemia with CD5+ Expression Presented as Cryoglobulinemic Glomerulonephropathy: A Case Report

• DOI: 10.3346/jkms.2011.26.6.824
• Publication Date: 2011-05-25T02:02:10Z
• Authors: You Lim Kim; Soo Jung Gong; Young Hwan Hwang; Jong Eun Joo; Young Uk Cho; Jung Ae Lee; Su Ah Sung; So Young Lee; Nae Yoo Kim
• Keywords: Lymphoplasmacytic Lymphoma; Lymphoproliferative Disorders; Macroglobulinemia; CD5; Gammopathy

Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that important for differential diagnosis disorders. In WM, various renal diseases type I cryoglobulinemia are well described separately, but cryoglobulinemic glomerulonephropathy very rarely reported. A 61-yr-old woman complained generalized edema, cyanosis the extremities cold weather, visual disturbance, pancytopenia. Bone biopsy showed CD5+ expressing B-cells glomerulonephropathy. With she received cyclophosphamide, doxorubicin, vincristine prednisolone chemotherapy got complete remission. Here, we report rare case WM unusual expression glomerulonephropathy, emphasize importance clinical features differentiating