Association between Glutathione S-Transferase T1, M1, and P1 Genotypes and the Risk of Colorectal Cancer

• DOI: 10.3346/jkms.2014.29.11.1488
• Publication Date: 2014-11-13T05:18:59Z
• Authors: Ning Cong; Lisheng Liu; Ying Xie; Wenbo Shao; Jinlong Song
• Keywords: GSTP1; Glutathione S-transferase

Glutathione S-transferases (GSTs) are enzymes which play an important role in the neutralization of toxic compounds and eradication electrophilic carcinogens.Genetic polymorphisms within genes encoding for GSTs may therefore cause variations their enzyme activity, turn influence interindividual susceptibility to cancers.In this study, we aimed investigate association between genetic GSTT1, GSTM1, GSTP1 risk colorectal cancer (CRC) 264 cases 317 controls a Chinese population.Genotyping was performed by using multiplex PCR (for GSTT1 GSTM1) PCR-RFLP GSTP1) methods.The polymorphic genotypes CRC evaluated deriving odds ratios (ORs) 95% confidence intervals (CIs) unconditional logistic regression analysis.Our results showed that individuals with GSTM1 null exhibited higher (GSTT1, OR,1.66; CI, 1.20-2.31,P = 0.003; OR,1.57; CI,1.13-2.18,P 0.007), while no observed (Pheterozygous 0.790 or Pvariant 0.261).Furthermore, who simultaneously carried both stronger (OR, 1.95; 1.33-2.85;P < 0.001).In conclusion, polymorphisms, but not GSTP1, modulate among Chinese.