Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism atTLR4

• DOI: 10.3346/jkms.2014.29.5.662
• Publication Date: 2014-04-29T07:34:58Z
• Authors: Seung-Hwa Lee; Mi-Jin Kang; Ho-Sung Yu; Kyungmo Hong; Young-Ho Jung; Hyung-Young Kim; Ju-Hee Seo; Ji-Won Kwon; Byoung-Ju Kim; Ha-Jung Kim; Young-Joon Kim; Hee-Suk Kim; Hyo Bin Kim; Kang Seo Park; So-Yeon Lee; Soo-Jong Hong
• Keywords: Acetaminophen; Bronchial hyperresponsiveness

The risk of asthma has been increasing in parallel with use acetaminophen, which is a potential source oxidative stress. Toll-like receptor 4 (TLR4) plays critical role not only innate immunity, but also mediating reactive oxygen species induced inflammation. Therefore, we investigated associations between acetaminophen usage and TLR4 polymorphism on bronchial hyperresponsiveness (BHR). number 2,428 elementary school children Seoul Jeongeup cities was recruited. Subjects who used family history had an increased both diagnosis ever current asthma. Individuals CT+TT genotypes at the polymorphism, combination usage, demonstrated (aOR, 2.08; 95% confidence interval [CI], 1.10-3.92). Family were factors for BHR. Although independent factor BHR, individuals BHR when combined 1.74; CI, 1.03-2.94). In conclusion, may be associated genetically susceptible subjects. This effect modified by TLR4.