Effects of Moderate Alcohol Intake in the Bladder of the Otsuka Long Evans Tokushima Fatty Diabetic Rats

• DOI: 10.3346/jkms.2015.30.9.1313
• Publication Date: 2015-08-17T10:00:49Z
• Authors: Woong Jin Bae; Yong Sun Choi; Su Jin Kim; Hyuk Jin Cho; Sung Hoo Hong; Sae Woong Kim; Tae-Kon Hwang; Dai Jin Kim; Ji Youl Lee
• Keywords: 0301 basic medicine; Alcohol Drinking; Ethanol; Rats, Inbred OLETF; Urinary Bladder; Rats; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Animals; Humans; Original Article; Reactive Oxygen Species

Effects of Moderate Alcohol Intake in the Bladder Otsuka Long Evans Tokushima Fatty Diabetic RatsDiabetes is related with a number cystopathic complications.However, there have been no studies about influence alcohol consumption bladder type 2 diabetes.Thus, we investigated effect moderate intake (OLETF) diabetic rat.The non-diabetic Long-Evans (LETO, n = 14) and OLETF control group (n were fed an isocaloric diet; LETO ethanol 36% 7 g/kg/day.After ten weeks, muscarinic receptors, RhoGEFs, myogenic change, level oxidative stress evaluated.Moderate significantly decreased excessive receptor Rho kinase expressions rats compared rats.In addition, iNOS collagen expression not changed spite consumption.Superoxide dismutase levels, which involved antioxidant defense, after consumption, however those similar.Moderate reduces stress, may prevent molecular pathologic changes diabetes.