COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis

2019-20 coronavirus outbreak
DOI: 10.3346/jkms.2020.35.e343 Publication Date: 2020-09-17T00:49:06Z
ABSTRACT
Observational studies of the ongoing coronavirus disease 2019 (COVID-19) outbreak suggest that a 'cytokine storm' is involved in pathogenesis severe illness. However, molecular mechanisms underlying altered pathological inflammation COVID-19 are largely unknown. We report here toll-like receptor (TLR) 4-mediated inflammatory signaling molecules upregulated peripheral blood mononuclear cells (PBMCs) from patients, compared with healthy controls (HC).
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