Sarcopenia as a Predictor of Prognosis in Early Stage Ovarian Cancer
Adult
Aged, 80 and over
Ovarian Neoplasms
Sarcopenia
Adolescent
Kaplan-Meier Estimate
Middle Aged
Prognosis
3. Good health
Young Adult
03 medical and health sciences
0302 clinical medicine
Humans
Original Article
Female
Muscle, Skeletal
Tomography, X-Ray Computed
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
DOI:
10.3346/jkms.2021.36.e2
Publication Date:
2020-12-01T05:28:55Z
AUTHORS (8)
ABSTRACT
To identify sarcopenia as a predictive prognostic factor of ovarian cancer in terms of survival outcome in patients with early-stage ovarian cancer.Data of Konkuk University Medical Center from March 2002 to December 2017 were reviewed retrospectively. Eighty-two patients who underwent surgery due to early-stage (International Federation of Gynecology and Obstetrics stage I/II) ovarian cancer and had computed tomography (CT) images taken at the initial diagnosis were included. The initial CT scan images were analyzed with SliceOmatic software (TomoVision). A sarcopenia cutoff value was defined as a skeletal muscle index of ≤ 38.7 cm²/m². Overall survival (OS) times were compared according to the existence of sarcopenia, and subgroup analyses were performed.A Kaplan-Meier analysis showed a significant survival disadvantage for patients with early-stage ovarian cancer when they had sarcopenia (P < 0.001; log-rank test). Sarcopenia remained a significant prognostic factor for OS in early-stage ovarian cancer, in a Cox proportional hazards model regression analysis (HR, 21.9; 95% CI, 2.0-199.9; P = 0.006).This study demonstrated that sarcopenia was predictive of OS in patients with early-stage ovarian cancer. Further prospective studies with a larger number of patients are warranted to determine the extent to which sarcopenia can be used as a prognostic factor in ovarian cancer.
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