Motor Asymmetry and Interocular Retinal Thickness in Parkinson's Disease

• DOI: 10.3346/jkms.2021.36.e50
• Publication Date: 2021-02-02T03:08:20Z
• Authors: Sung Uk Baek; Suk Yun Kang; Soonil Kwon; In Won Park; Wool Suh
• Keywords: Male; Parkinson Disease; Middle Aged; Retina; 03 medical and health sciences; Nerve Fibers; 0302 clinical medicine; Case-Control Studies; Humans; Original Article; Female; Prospective Studies; Tomography, Optical Coherence; Aged

Background To analyze the relationship between interocular difference of retinal thickness and motor asymmetry in Parkinson's disease (PD). Methods Prospective case-control series analyzed 62 eyes 31 patients with PD age- sex-matched control. Ophthalmologic examinations including optical coherence tomography (OCT) scans were performed both groups, PD, function was evaluated on Unified Disease Rating Scale part III (UPDRS-III) to determine clinically more affected side. Peripapillary nerve fiber layer (pRNFLT) macular (mRT) measured eyes, after which OCT parameters determined. Additionally, less sides UPDRS-III using Symmetric index. Results The average quadrant pRNFLT mRT values two groups not different, but index (AIRT) temporal significantly higher than controls (P = 0.026 0.044). sum showed a discrepancy 0.002); calculated 0.21 ± 0.19, suggested asymmetric symptoms. significant relations for superior AIRT 0.001 0.008). Conclusion In patients, larger controls, symptoms asymmetric. correlation motor-symptom laterality.