Inflammatory Cytokine and Osmolarity Changes in the Tears of Dry Eye Patients Treated with Topical 1% Methylprednisolone

• DOI: 10.3349/ymj.2014.55.1.203
• Publication Date: 2013-12-11T01:53:51Z
• Authors: Ji Hwan Lee; Kyung Min; Se Kyung Kim; Eung Kweon Kim; Tae-im Kim
• Keywords: Osmotic concentration; Artificial tears

Purpose: To evaluate changes in clinical outcomes, inflammatory cytokine levels, and tear osmolarity the tears of patients with moderate to severe dry eye syndrome before after application topical 1% methylprednisolone.Materials Methods: Thirty-two unresponsive previous aqueous enhancement therapy were enrolled.Five lost follow up, twenty-seven eligible for analysis.Patients instructed apply methylprednisolone four times per day, as well continue applying their current preservative-free 0.1% sodium hyaluronate day.Corneal conjunctival staining scores, film breakup time (TFBUT), Schirmer test, assessed at baseline, 4 weeks, 8 weeks.Tear samples collected every visit analysis.Results: Corneal scores TFBUT showed significant improvement (p<0.001,<0.001, <0.001 respectively) decreased significantly weeks (p=0.008).Interleukin (IL)-1β, IL-8, monocyte chemoattractant protein-1 compared those baseline (p=0.041,0.001, 0.008 respectively).Conclusion: Short-term treatment not only improved but also levels.By measuring levels osmolarity, we could objectively anti-inflammatory effects applied syndrome.