Composite liver tumors: A radiologic-pathologic correlation

• DOI: 10.3350/cmh.2014.20.4.406
• Publication Date: 2014-12-27T00:25:31Z
• Authors: Megha Nayyar; David K. Imagawa; Temel Tirkes; Aram N. Demirjian; Roozbeh Houshyar; Kumar Sandrasegaran; Chaitali S. Nangia; Tara Seery; P Bhargava; Joon II Choi; Chandana Lall
• Keywords: Liver Cancer; Carcinoma, Hepatocellular; CA-19-9 Antigen; Oncology and Carcinogenesis; Clinical sciences; Hepatoceullular carcinoma; Bi-phenotypic tumors; RC799-869; Cholangiocarcinoma; 03 medical and health sciences; Rare Diseases; Magnetic resonance imaging; 0302 clinical medicine; Risk Factors; Humans; Tomography; Computed tomography; Cancer; Biomedical and Clinical Sciences; Liver Disease; Carcinoma; Liver Neoplasms; Liver Imaging; Hepatocellular; Diseases of the digestive system. Gastroenterology; Stem Cell Research; Magnetic Resonance Imaging; Survival Analysis; X-Ray Computed; 3. Good health; Phenotype; alpha-Fetoproteins; Digestive Diseases; Tomography, X-Ray Computed; Computed tomography, Magnetic resonance imaging

Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.