Serotonin Modulates Outward Potassium Currents in Mouse Olfactory Receptor Neurons

• DOI: 10.33549/physiolres.932413
• Publication Date: 2020-07-29T07:16:57Z
• Authors: S. GAO; X. GUO; T. LIU; J. LIU; W. CHEN; Q. XIA; Y. CHEN; Y. TANG
• Keywords: Monoaminergic; Neurotransmitter receptor

Monoaminergic neurotransmitter 5-hydroxytryptamine (5-HT), also known as serotonin, plays important roles in modulating the function of olfactory system. However, thus far, knowledge about 5-HT and its receptors receptor neurons (ORNs) their physiological role have not been fully characterized. In present study, reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed presence 5-HT1A 5-HT1B subtypes mouse epithelium at mRNA level. With subtype selective antibodies standard immunohistochemical techniques, both were found to be positively labeled. To further elucidate molecular mechanisms act on peripheral transduction, whole-cell patch clamp techniques used freshly isolated ORNs. We that decreased magnitude outward K+ current a dose-dependent manner these inhibitory effects markedly attenuated by blocker WAY-100635 antagonist GR55562. These data suggested may play modulation signals regulating potassium currents, involved this regulation.