Antitumor Potential of Fibulin-5 in Breast Cancer Cells Depends on Its RGD Cell Adhesion Motif

• DOI: 10.33594/000000123
• Publication Date: 2019-06-17T07:20:26Z
• Authors: Yamina Mohamedi; Tania Fontanil; Teresa Cobo; José A. Vega; Juan L. Cobo; Marcos Pérez‐Bast...; Juan Cobo; Álvaro J. Obaya; Santiago Cal
• Keywords: Matrigel; Fibulin; RGD motif; Tumor progression; Crosstalk

Different components of the tumor microenvironment can be either tumor-promoting or tumor-suppressive agents depending on factors which are not fully understood. Fibulins extracellular matrix from different tissues and constitute a clear example this dual function. In fact, fibulins may support growth abolish progression malignant cells crosstalk between their surrounding stroma through mechanisms that remain to elucidated. Among all fibulins, fibulin-5 contains particular structural hallmark consists in presence RGD motif within its architecture. Previous reports have highlighted importance interaction with integrins, only normal functions but also context.