Hair Follicle Stem Cells: the Signaling Hub of the Skin

• DOI: 10.33696/immunology.6.187
• Publication Date: 2024-02-27T04:32:12Z
• Authors: Yongci Tan; Haocai Chang

Hair follicle stem cells (HFSCs) are recognized as multipotential with exceptional proliferative capacity. Their regulatory effect on skin homeostasis is orchestrated through intricate signaling pathways, including Wnt/β-catenin, transforming growth factor-β/bone morphogenetic protein (TGFβ/BMP), Notch, and Hedgehog. Concurrently, HFSCs inhabit the bulge region of outer root sheath hair (HF), serving epicenter for skin-organizing during homeostasis, engaging in dynamic interactions other functionally specialized niche cells. This comprehensive review delineates nuanced interplay both cell-intrinsic cell-extrinsic mechanisms governing within skin. The aspiration that this synthesis knowledge will contribute meaningfully to theoretical foundations underpinning further investigations into disorders.