Effect of Sappan Wood Ethanol Extract in CRP Level and Phagocytic Index Between Group of Mice Infected with S. aureus and E. coli

• DOI: 10.33751/jf.v14i1.10040
• Publication Date: 2024-08-05T05:01:52Z
• Authors: Martina Kurnia Ro...; A'yunil Hisbiyah; Amellya Octivani; Farida Anwari

S.aureusand E.coli are pathogenic bacterial that cause many infectious disease in the world. Immunomodulator is needed to prepare immune system be able against infection. Some parameters usually used assess immunomodulatory activity such as C-Reactive Protein (CRP) and phagocytic index. This study aims investigate difference effect of sappan1wood extract CRP level index between group mice infected with S. aureus E. coli. Two treatment groups were prepared for coli test. Each subjected 7 treatments i.e. (1) Normal mice1(CMC-Na 1 %- Merck® 217277), 1(2) Negative Control (bacterial infection + CMC-Na %),11(3) Positive Imboost force®1treatment, PT SOHO Industri Pharmasi), (4) Bacterial EESW 25 mg/kg BW, (5) 50 (6) 100 (7) 200 BW. Mice blood was taken detect after treatment. The T test showed there a significant levels (p0.05) group. BW reduced 11 mg/dL (S. aureus) 6 (E. coli). increased phagocytosis 1.54 folds 4.62 Sappan wood ethanol index1in better than aureus1infection