The case for monitoring metabolic and inflammatory elevated risk groups in young people with emerging mental disorders

• DOI: 10.33774/coe-2024-4g922
• Publication Date: 2024-08-05T08:08:30Z
• Authors: Mirim Shin; Jacob Crouse; Alissa Nichles; Natalia Zmicerevska; Christine Song; Minji Park; Daniel Froggatt; Connie Janiszewski; Karina Chan; Dagmar Koethe; Blake Hamilton; Joanne Carpenter; Frank Iorfino; Sarah Mckenna; Elizabeth Scott; Ian Hickie

We investigated the prevalence of elevated metabolic and inflammatory risk groups in youth seeking care for emerging mental disorders. Among 124 participants (27.3±5.9 years), we analysed fasting insulin (FI), blood glucose (FBG), homeostasis model assessment resistance (HOMA2-IR), C-reactive Protein (CRP). FI (≥10mU/L) CRP (≥1mg/L) were used to categorise metabolic- or inflammatory-risk groups, demographic/clinical features compared. Inflammatory was common (58% [n=73] with CRP), as (38% [n=47] FI). Notably, 25% (n=31) had HOMA2-IR, while only 7% (n=9) abnormal FBG. Elevated-risk poorer physical health, group comprised more major mood Elevated dysfunction is disorders associated clinical features. Early detection monitoring these markers early intervention health services needed.