Local clinical trials in low-to-middle income countries as an ethical alternative to high-income country-led trials

• DOI: 10.33774/coe-2024-wf61g
• Publication Date: 2024-04-28T00:21:12Z
• Authors: Esmeralda Garza-S...; Javier Mancilla-G...; Ashuin Kammar-García
• Keywords: Middle income; High income countries; Middle income country

Background: Most clinical trials are registered to be conducted in high-income countries (HIC), whereas low-to-middle income (LMIC) account for 32%. Building a non-HIC dependent trial research capacity LMIC is priority. However, certain ethical principles could jeopardized the process. Objective: To explore conditions ethically conduct independently from HIC. Material and Methods: Analysis ten Principles Benchmarks Ethical Clinical Research by Emanuel EJ, et al. A non-systematic search of literature was carried out identify studies that cover problems potential solutions independent LMICs. Results: Three were coincided with notion HIC-led often do not guarantee equitable distribution funds publication credits. Alternative designs proposed. Conclusion: International collaboration between HIC based on equity partners harmonize compared strictly locally-initiated or trials.