Effects of swine gut antimicrobial peptides on the intestinal mucosal immunity in specific-pathogen-free chickens

• DOI: 10.3382/ps.2008-00533
• Publication Date: 2009-04-09T22:43:59Z
• Authors: D. Wang; W. Ma; R. She; Qu. Sun; Y. Liu; Y. Hu; L. Liu; Y. Yang; K. Peng
• Keywords: Jejunum; Intraepithelial lymphocyte; Specific-pathogen-free; Mucosal Immunity

Sixty specific-pathogen-free chickens were randomly divided into 2 groups (30 for each group) to determine the effect of swine gut antimicrobial peptides (SGAMP) on intestinal mucosal immunity. All raised in negative-pressure isolators and fed same diet. The results as follows. (1) In SGAMP group, number mast cells was increased markedly duodenum from d 21 49 (P < 0.05), similar observed jejunum ileum after being treated with 0.05). However, fewer those tissues control. (2) Intraepithelial lymphocytes duodenum, jejunum, significantly group compared control (3) Compared control, goblet 35 0.05) treatment (4) Swine upgrade expression secretory IgA at different sites within tract. strongly support that can enhance immune parameters chickens. Our research contributes further understanding immunoregulatory mechanisms immunity contribution this process.