Bone Quantification Around Chitosan-Coated Titanium Dental Implants: A Preliminary Study by Micro-CT Analysis in Jaw of a Canine Model

• DOI: 10.3389/fbioe.2022.858786
• Publication Date: 2022-04-07T18:59:21Z
• Authors: Nansi López-Valverde; Antonio López-Val...; Marta Paz Cortés; Cinthia Rodríguez; Bruno Macedo De S...; Juan Manuel Arago...
• Keywords: Biomaterial; X-ray microtomography

Surface treatments of Ti in the dental implant industry are performed with aim in-creasing its bioactivity and osseointegration capacity. Chitosan (Cht) is a polysaccharide that has been proposed as promising biomaterial tissue engineering bone regeneration, due to ability stimulate recruitment adhesion osteogenic progenitor cells. The our preliminary study was evaluate, by micro-computed tomography (micro-CT), formation around Cht-coated implants compare them conventional surface-etched (SLA type). Four im-plants (8.5 mm length × 3.5 Ø) per hemiarch, were inserted into jaws five dogs, divided two groups: chitosan-coated group (ChtG) control (CG). Twelve weeks after surgery, euthanasia performed, sectioned blocks obtained scanned micro-CT parameters measured: contact surface (BCIS) peri-implant area (PIBA). For BCIS PIBA statistically significant values for ChtG respect CG (p = 0.005; p 0.014 < 0.001 0.002, respectively). results, despite limitations, demonstrated usefulness chitosan coatings. However, studies larger sample sizes adequate experimental models would be necessary confirm results.