A personalized biomimetic dual-drug delivery system via controlled release of PTH1-34 and simvastatin for in situ osteoporotic bone regeneration

• DOI: 10.3389/fbioe.2024.1355019
• Publication Date: 2024-01-31T11:52:53Z
• Authors: Tongtong Xu; Shang Gao; Nan Yang; Qi Zhao; Yutong Zhang; Tieshu Li; Zhihui Liu; Bing Han
• Keywords: 0301 basic medicine; PTH1-34; 0303 health sciences; bone regeneration; drug delivery system; simvastatin; Bioengineering and Biotechnology; osteoporosis; TP248.13-248.65; Biotechnology

Patients with osteoporosis often encounter clinical challenges of poor healing after bone transplantation due to their diminished formation capacity. The use substitutes containing bioactive factors that increase the number and differentiation osteoblasts is a strategy improve healing. In this study, we developed an