Oral origin of the placenta microbiome in pregnant women with preeclampsia

• DOI: 10.3389/fbrio.2023.1322165
• Publication Date: 2024-03-14T05:03:20Z
• Authors: Shontreal M. Cooper; Adam Borgida; Sejal Thacker; Erica Hammer; Amirtha Hariharan; ChiaLing Kuo; Nyle Blanck; Hanshu Yuan; Hunter Panier; Qingqi Lin; Kendra Maas; Winston Campbell; Yanjiao Zhou
• Keywords: Oral Microbiome

Preeclampsia (PE) is a leading cause of morbidity and mortality in pregnancy with elusive etiology. Patients PE are thought to be associated higher rate periodontal diseases (PDs) changes oral bacteria targeted PCR techniques. However, few studies have investigated the associations between microbiome dysbiosis secondarily disseminated microbes placenta simultaneously patients PE. The association detected systemic inflammation also unclear. We enrolled 54 pregnant without PD, profiled subgingival by V4 region 16S rRNA gene sequencing. Systemic inflammatory markers tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), lipopolysaccharide binding (LBP), interleukins 6 8 (IL-6 IL-8) blood were measured ELISA. found that PD significantly increased risk after adjusting for age smoking status (OR = 2.26, 95% CI 1.14–4.48, p 0.024). A combined group oral-associated Veillonella , Fusobacterium Haemophilus Granulicatella Streptococcus, Gemella Neisseria had prevalence women compared (53.8% vs. 19.0%, 0.018), highest both (58.8%). relative abundance Haemophilus, samples was than those 2.11, 1.11–4.52, 0.032). Proinflammatory cytokine analysis showed IL-8 levels ( 0.026). CRP, LBP, TNF-α no statistical difference or PD. Blood IL-6 detectable 0.028). Together, our data suggest potential origin placental microbiota present PE, level blood.