Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain

• DOI: 10.3389/fcell.2021.619538
• Publication Date: 2021-07-15T12:46:23Z
• Authors: Eman Abbas; Mohamed A. Hassan; Godwin Sokpor; Kamila Kiszka; Linh Pham; Cemil Kerimoglu; Andre Fischer; Huu Phuc Nguyen; Jochen F. Staiger; Tran Tuoc
• Keywords: Forebrain; Conditional gene knockout; Gliogenesis; Progenitor

Oligodendrocytes are responsible for axon myelination in the brain and spinal cord. Generation of oligodendrocytes entails highly regulated multistage neurodevelopmental events, including proliferation, differentiation maturation. The chromatin remodeling BAF (mSWI/SNF) complex is a notable regulator neural development. In our previous studies, we determined indispensability scaffolding subunits BAF155 BAF170 neurogenesis, whereas their role gliogenesis unknown. Here, show that expression essential genesis during We report ablation dorsal telencephalic (dTel) progenitors or oligodendrocyte-producing ventral telencephalon (vTel) double-conditional knockout (dcKO) mouse mutants, perturbed process oligodendrogenesis. Molecular marker cell cycle analyses revealed impairment oligodendrocyte precursor specification as well overt depletion pool dcKO mutants. Our findings unveil central oligodendrogenesis, thus substantiate involvement production forebrain.