Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury

• DOI: 10.3389/fcell.2021.637270
• Publication Date: 2021-07-05T06:42:06Z
• Authors: S. Sakinah; Sivan Padma Priya; Pooi Ling Mok; Rusheni Munisvara...; Seoh Wei Teh; Zhong Sun; Badr Alzahrani; Faizal Abu Bakar; Hui-yee Chee; Rukman Awang Hamat; Guozhong He; Chenglong Xiong; Narcisse Joseph; Jia Bei Tong; Xiaoyun Wu; Mahendran Maniam; Antony V. Samrot; Akon Higuchi; S. Suresh Kumar
• Keywords: Hematopoietic stem cell

Extensive clinical efforts have been made to control the severity of dengue diseases; however, morbidity and mortality not declined. Dengue virus (DENV) can infect cause systemic damage in many organs, resulting organ failure. Here, we present a novel report showing tailored stem-cell-based therapy that aid viral clearance rescue liver cells from further during infection. We administered combination hematopoietic stem endothelial progenitor DENV-infected BALB/c mouse model found delivery this cell cocktail had improved their functions, confirmed by hematology, histopathology, next-generation sequencing. These differentiate into target repair damaged tissues. In addition, regime regulate proliferation permeability, modulate inflammatory reactions, enhance extracellular matrix production angiogenesis, secrete an array growth factors create enhanced milieu for reparation. No previous study has published on treatment infection using combination. conclusion, dengue-induced was rescued administration therapy, with less apoptosis regeneration model.