Molecular Behavior of HMGB1 in the Cochlea Following Noise Exposure and in vitro

• DOI: 10.3389/fcell.2021.642946
• Publication Date: 2021-02-25T07:48:08Z
• Authors: Lili Xiao; Yan Sun; Chengqi Liu; Zhong Zheng; Ying Shen; Liang Xia; Guang Yang; Yanmei Feng
• Keywords: HMGB1; Noise-induced hearing loss; Damp; Mediator; Pathogenesis

Noise-induced hearing loss (NIHL) is characterized by cellular damage to the inner ear, which exacerbated inflammation. High-mobility group box 1 (HMGB1), a representative damage-associated molecular pattern (DAMP), acts as mediator of inflammation or an intercellular messenger according its localization. Blocking regulating HMGB1 offers attractive approach in ameliorating NIHL. However, precise therapeutic intervention must be based on deeper understanding dynamic distribution and function cochlear pathogenesis after acoustic trauma. Here, we have presented spatiotemporal dynamics expression HMGB1, exhibiting variability specific regions cells following noise exposure. After gene manipulation, further investigated characteristics HEI-OC1 cells. The higher cell viability observed knocked-down stimulation with H 2 O indicated possible negative effect lifespan. In conclusion, this study demonstrated that involved NIHL biology has essential subtle influences, preserving translational potential for pharmacological intervention.