Identifying a Ferroptosis-Related Gene Signature for Predicting Biochemical Recurrence of Prostate Cancer

• DOI: 10.3389/fcell.2021.666025
• Publication Date: 2021-10-29T06:23:11Z
• Authors: Zhengtong Lv; Jianlong Wang; Xuan Wang; Miao Mo; Guyu Tang; Haozhe Xu; Jianye Wang; Yuan Li; Ming Liu
• Keywords: Gene signature; Biochemical recurrence

Ferroptosis induced by lipid peroxidation is closely related to cancer biology. Prostate (PCa) not only a malignant tumor but also metabolic disease. Previous studies have identified ferroptosis as an important pathophysiological pathway in PCa development and treatment, its role the prognosis of less well known. In this study, we constructed nine-ferroptosis-related gene risk model that demonstrated strong prognostic therapeutic predictive power. The higher score calculated was significantly associated with potential index, Ki67 expression, immune infiltration, probability biochemical recurrence, worse clinicopathological characteristics, response chemotherapy antiandrogen therapy PCa. mechanisms set enrichment analysis suggested signature can accurately distinguish high- low-risk populations, which possibly variations steroid hormone secretion, regulation endocrine processes, positive humoral response, androgen response. Results study were confirmed two independent cohorts, namely, Cancer Genome Atlas cohort MSK-IMPACT Clinical Sequencing Cohort, contributed body scientific evidence for prediction recurrence patients addition, main components signature, effects AIFM2 NFS1 genes on evaluated verified vivo vitro experiments, respectively. above findings provided new insights presented clinical applications